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For each muscle sample, more than 50 fibres (mean 227) were individually analysed in order to obtain a robust morphometric analysis [23]. Based on the staining pattern for the different MyHC mAbs, the fibers were classified as fibers containing solely MyHCI, MyHCIIa or MyHCIIx, or as hybrid fibers co-expressing two MyHC isoforms: MyHCI+IIa or MyHCIIa+IIx. Detailed description of fiber type classification has been described in our earlier study [24]. Estimation of fiber area and number of capillary has been described in detail in a publication from our laboratory [21], max mass gainer.
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